IL-4 inhibits regulatory T cells differentiation by HDAC9-mediated epigenetic regulation
Abstract Regulatory T cells play a crucial role in orchestrating immune response and maintaining immune tolerance, and the expression of the Foxp3 gene 9x11 pergola is indispensable to the differentiation of regulatory T cells.IL-4 shows strong inhibitory effects on Foxp3 expression and regulatory T cells differentiation, but the detailed mechanism